The radial flow chromatography technique is different from the traditional axial flow chromatography technique. In the radial column , the mobile phase carries the sample move along the radial direction. In a radial-flow column, the mobile phase and the sample can flow from the outer annulus of the column to the center of the column.

The radial column is composed of two annulus (see Figure.1). The area of the outer annulus is significantly larger than that of the inner annulus. A cavity is formed between the inner and outer annulus. The sample permeates through the entire outer annulus to the inner annulus, and finally the sample gathers with the inner annulus and exits through the lower port.

Pack and unpack of radial column

Product features:1) The flow rate is faster, the chromatographic efficiency is increased by more than 4 times, and the process development time is greatly shortened2) Lower column back pressure, the wedge column can use the 15μm particle size or even below resin which can not be used in current process because of the pressure limited3) Easy to scale up, better process scale up consistency, and smaller footprint after scale up4) Better column efficiency and separation trend5) Prevent concentration dependent precipitation and improve the yield6) Easy to use, no need to disassemble to achieve resin packing and unpacking

Application Case:1) Pressure comparison of ovalbumin separation system between radial chromatographic column and traditional axial column
2) Comparison of protease purification expressed by E. coli isolated by radial chromatographic column and traditional axial column

Order List：

Name

Application

Cat.no

Volume

Bed depth

Diagram

acrylic pre-pack column

Lab scale

PP-0050-00

50mL

3.5cm

PP-0100-00

100mL

3.5cm

PP-0250-00

250mL

3.5cm

PP-0350-00

350mL

3.5cm

PP-0500-00

500mL

3.5cm

PP-1000-00

1L

3.5cm

Superflo column

Lab scale

10-0050-00

50mL

3.5cm

10-0100-00

100mL

3.5cm

10-0250-00

250mL

3.5cm

10-0500-00

500mL

3.5cm

10-1000-00

1L

3.5cm

10-1500-00

1.5L

3.5cm

Superflo column

Pilot scale

11-002K-00

2L

5cm

11-003K-00

3L

5cm

11-005K-00

5L

5cm

11-07.5K-00

7.5L

5cm

Superflo column

Production scale

11-010L-00

10L

10cm

11-020L-00

20L

10cm

11-030L-00

30L

10cm

11-040L-00

40L

10cm

11-050L-00

50L

10cm

11-060L-00

60L

10cm

11-070L-00

70L

10cm

Superflo stainless column

Lab scale

13-0100-00

100mL

3.5cm

13-0250-00

250mL

3.5cm

13-0500-00

500mL

3.5cm

13-1000-00

1L

3.5cm

13-1500-00

1.5L

3.5cm

Superflo stainless column

Pilot scale

13-005K-00

5L

5cm

13-010K-00

10L

5cm

13-015K-00

15L

5cm

Superflo stainless column

Production scale

13-010L-00

10L

10cm

13-015L-00

15L

10cm

13-020L-00

20L

10cm

13-025L-00

25L

10cm

13-030L-00

30L

10cm

13-040L-00

40L

10cm

13-050L-00

50L

10cm

13-060L-00

60L

10cm

13-070L-00

70L

10cm

13-080L-00

80L

10cm

13-090L-00

90L

10cm

13-100L-00

100L

10cm

custom-made

Production scale

custom-made 110-400L Superflo column